New molecular mediators in tumor angiogenesis

Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels. Angiogenesis is regulated by several endogenous stimulators and inhibitors of endothelial cell migration, proliferation and tube formation. Under physiological conditions these mediators of endothelial cell growth are in balance and vessel growth is limited. In fact, within the angiogenic balance endothelial cell turnover is sufficient to maintain a functional vascular wall but does not allow vessel growth. Tumor growth an progression has successfully been correlated to the serum concentration of angiogenic mediators. Furthermore, the vascular density of tumor tissues could be correlated to the clinical course of the disease in several tumor entities. Within the last years several new mediators of endothelial cell growth have been isolated e.g. angiopoietin 1, angiopoietin 2, midkine, pleiotropin, leptin and maspin. In this review we discuss the mechanisms leading to tumor angiogenesis and describe some of the newer mediators of endothelial cell stimulation and inhibition

Quarkonia Measurements with the Central Detectors of ALICE

A Large Ion Collider Experiment - ALICE will become operational with the startup of the Large Hadron Collider - LHC at the end of 2007. One focus of the physics program is the measurement of quarkonia in proton-proton and lead-lead collisions. Quarkonia states will be measured in two kinematic regions and channels: di-muonic decays will be measured in the forward region by the muon arm, the central part of the detector will measure di-electronic decays. The presented studies show the expected performance of the di-electron measurement in proton-proton and central lead-lead collisions.Comment: 6 pages, 7 figures, Proceedings of the QM 2006 poster sessio

Feasibility Conditions of Interference Alignment via Two Orthogonal Subcarriers

Conditions are derived on line-of-sight channels to ensure the feasibility of interference alignment. The conditions involve choosing only the spacing between two subcarriers of an orthogonal frequency division multiplexing (OFDM) scheme. The maximal degrees-of-freedom are achieved and even an upper bound on the sum-rate of interference alignment is approached arbitrarily closely.Comment: Submitted to ISIT 201

Abort Gap Cleaning using the Transverse Feedback System: Simulation and Measurements in the SPS for the LHC Beam Dump System

The critical and delicate process of dumping the beams of the LHC requires very low particle densities within the $3 \mu$s of the dump kicker rising edge. High beam population in this so-called 'abort gap' might cause magnet quenches or even damage. Constant refilling due to diffusion processes is expected which will be counter-acted by an active abort gap cleaning system employing the transverse feedback kickers. In order to assess the feasibility and performance of such an abort gap cleaning system, simulations and measurements with beam in the SPS have been performed. Here we report on the results of these studies

A general purpose HyperTransport-based Application Accelerator Framework

HyperTransport provides a flexible, low latency and high bandwidth interconnection between processors and also between processors and peripheral omponents. Therefore, the interconnection is no longer a performance bottleneck when integrating application specific accelerators in modern computing systems. Current FPGAs providing huge computational power and permit the acceleration of compute-intensive kernels. We therefore present a general purpose architecture based on HyperTransport and modern FPGAs to accelerate time-consuming computations. Further, we present a prototypical implementation of our architecture. Here we used an AMD Opteron-based system with the HTX Board [6] to demonstrate that common applications can benefit from available hardware accelerators. A cryptographic example showed that the encryption of files, larger then 50 kByte, can be successfully accelerated

Locally compact abelian p-groups revisited

Even though the structure of locally compact abelian groups is generally considered to be rather thoroughly known through a wealth of publications, one keeps encountering corners that are not elucidated in up-to-date literature. In a study of a particular class of metabelian locally compact groups (see [HHR17]) we encountered some issues about noncompact locally compact abelian groups which do not appear to be discussed in the literature even though some of them were anticipated in Braconnier's article on his local product [Bra48]. Here we treat some of them, notably some aspects of totally disconnected torsion-free locally compact abelian groups which one might consider unexpected if not pathological. However, firstly we deal with some points concerning noncompact locally compact abelian torsion groups. For compact abelian groups we often refer to the monograph [HM13]. It will be convenient to use additive notation for abelian groups

Beobachtungen zur Fauna im Kreis Höxter : Schlangenadler ; Haselmaus

Der Artikel befasst sich mit der Verbreitung von Haselmaus und Schlangenadler im Kreis Höxter